L10P (p.Leu10Pro) variant of PIK3CA (P42336)
L10P (p.Leu10Pro) in PIK3CA (P42336) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes structural context.
L10P (p.Leu10Pro) variant details
- p.Leu10Pro
- rs2108385050
- ClinGen CA355270329
- cosmic curated COSV55969
- ClinVar RCV003225477
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.585
- AlphaMissense 0.99
- MetaLR 0.56
- MetaSVM 0.19
- PolyPhen-2 1.00
- SIFT 0.15
- MutPred 0.56
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available