G12D (p.Gly12Asp) variant of PIK3CA (P42336)
G12D (p.Gly12Asp) in PIK3CA (P42336) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
G12D (p.Gly12Asp) variant details
- p.Gly12Asp
- NCI-TCGA Cosmic COSV5589
- cosmic curated COSV55899
- Ensembl rs2108385083
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.59
- REVEL 0.58
- MetaLR 0.50
- MetaSVM -0.07
- CADD 25.90
- PolyPhen-2 0.98
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available