G12C (p.Gly12Cys) variant of PIK3CA (P42336)
G12C (p.Gly12Cys) in PIK3CA (P42336) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
G12C (p.Gly12Cys) variant details
- p.Gly12Cys
- cosmic curated COSV55908
- Ensembl rs2108385075
- Missense
- Variant Prioritization Score for Impact Estimate 0.639
- REVEL 0.66
- MetaLR 0.56
- MetaSVM 0.14
- CADD 25.20
- PolyPhen-2 1.00
- SIFT 0.03
- Population evidence available
- Structural context available