F25L (p.Phe25Leu) variant of PIEZO2 (Q9H5I5)
F25L (p.Phe25Leu) in PIEZO2 (Q9H5I5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
F25L (p.Phe25Leu) variant details
- p.Phe25Leu
- TOPMed rs1036820674
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.35
- ESM-1b 0.00
- AlphaMissense 0.92
- MetaLR 0.23
- MetaSVM -0.72
- CADD 24.60
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available