L59M (p.Leu59Met) variant of PICALM (Q13492)
L59M (p.Leu59Met) in PICALM (Q13492) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
L59M (p.Leu59Met) variant details
- p.Leu59Met
- gnomAD rs1012378518
- Missense
- Variant Prioritization Score for Impact Estimate 0.427
- REVEL 0.23
- CADD 22.50
- PolyPhen-2 0.98
- SIFT 0.34
- Most common in the Non-Finnish European population (allele frequency 3.8e-05)
- Structural context available