K149R (p.Lys149Arg) variant of PICALM (Q13492)
K149R (p.Lys149Arg) in PICALM (Q13492) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
K149R (p.Lys149Arg) variant details
- p.Lys149Arg
- TOPMed rs1297090510
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.25
- CADD 24.90
- PolyPhen-2 0.03
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available