Y87H (p.Tyr87His) variant of PGR (Progesterone receptor)
Y87H (p.Tyr87His) in PGR (Progesterone receptor) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
Y87H (p.Tyr87His) variant details
- p.Tyr87His
- ExAC rs751679548
- TOPMed rs751679548
- gnomAD rs751679548
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.04
- CADD 22.30
- PolyPhen-2 0.48
- SIFT 0.05
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 0.00058)
- Structural context available