T74M (p.Thr74Met) variant of PGR (Progesterone receptor)
T74M (p.Thr74Met) in PGR (Progesterone receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
T74M (p.Thr74Met) variant details
- p.Thr74Met
- cosmic curated COSV54800
- TOPMed rs1862995082
- gnomAD rs1862995082
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.06
- CADD 23.00
- PolyPhen-2 0.83
- SIFT 0.00
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available