T44N (p.Thr44Asn) variant of PGR (Progesterone receptor)
T44N (p.Thr44Asn) in PGR (Progesterone receptor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
T44N (p.Thr44Asn) variant details
- p.Thr44Asn
- rs141862537
- NCI-TCGA Cosmic COSV5479
- cosmic curated COSV54795
- ESP rs141862537
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.096
- REVEL 0.03
- CADD 8.24
- PolyPhen-2 0.02
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-05)
- Structural context available