P37R (p.Pro37Arg) variant of PGR (Progesterone receptor)
P37R (p.Pro37Arg) in PGR (Progesterone receptor) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.03 / 1. The record also includes population frequency data and structural context.
P37R (p.Pro37Arg) variant details
- p.Pro37Arg
- ESP rs146230124
- ExAC rs146230124
- TOPMed rs146230124
- gnomAD rs146230124
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.0267
- REVEL 0.00
- CADD 0.51
- PolyPhen-2 0.00
- SIFT 0.25
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the HGDP:PIMA population (allele frequency 0.045)
- Structural context available