P21S (p.Pro21Ser) variant of PGR (Progesterone receptor)
P21S (p.Pro21Ser) in PGR (Progesterone receptor) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P21S (p.Pro21Ser) variant details
- p.Pro21Ser
- cosmic curated COSV54805
- ExAC rs770746610
- TOPMed rs770746610
- gnomAD rs770746610
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.05
- CADD 16.80
- PolyPhen-2 0.15
- SIFT 0.07
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Middle Eastern population (allele frequency 0.00018)
- Structural context available