P121S (p.Pro121Ser) variant of PGR (Progesterone receptor)
P121S (p.Pro121Ser) in PGR (Progesterone receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
P121S (p.Pro121Ser) variant details
- p.Pro121Ser
- gnomAD rs1193989741
- Missense
- Variant Prioritization Score for Impact Estimate 0.231
- REVEL 0.14
- CADD 22.60
- PolyPhen-2 0.49
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available