G66A (p.Gly66Ala) variant of PGR (Progesterone receptor)
G66A (p.Gly66Ala) in PGR (Progesterone receptor) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G66A (p.Gly66Ala) variant details
- p.Gly66Ala
- TOPMed rs1391427840
- gnomAD rs1391427840
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.01
- CADD 6.27
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available