L15I (p.Leu15Ile) variant of PDCD1 (Programmed cell death protein 1)
L15I (p.Leu15Ile) in PDCD1 (Programmed cell death protein 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
L15I (p.Leu15Ile) variant details
- p.Leu15Ile
- gnomAD rs1268978816
- Missense
- Variant Prioritization Score for Impact Estimate 0.292
- REVEL 0.17
- MetaLR 0.32
- MetaSVM -0.75
- CADD 22.50
- PolyPhen-2 0.98
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available