V15G (p.Val15Gly) variant of PBRM1 (Protein polybromo-1)
V15G (p.Val15Gly) in PBRM1 (Protein polybromo-1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V15G (p.Val15Gly) variant details
- p.Val15Gly
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.09
- CADD 23.60
- PolyPhen-2 0.04
- SIFT 0.01
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- PBRM1 High mobility group box domain domainome 1.0: score -0.0654