W58R (p.Trp58Arg) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
W58R (p.Trp58Arg) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
W58R (p.Trp58Arg) variant details
- p.Trp58Arg
- cosmic curated COSV10747
- ESP rs370621373
- ExAC rs370621373
- TOPMed rs370621373
- Missense
- Variant Prioritization Score for Impact Estimate 0.706
- REVEL 0.72
- CADD 31.00
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available