V85I (p.Val85Ile) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
V85I (p.Val85Ile) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
V85I (p.Val85Ile) variant details
- p.Val85Ile
- gnomAD rs1254416670
- Missense
- Variant Prioritization Score for Impact Estimate 0.251
- REVEL 0.02
- CADD 12.60
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the East Asian population (allele frequency 0.00015)
- Structural context available