S4F (p.Ser4Phe) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
S4F (p.Ser4Phe) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
S4F (p.Ser4Phe) variant details
- p.Ser4Phe
- TOPMed rs1347824092
- gnomAD rs1347824092
- Missense
- Variant Prioritization Score for Impact Estimate 0.246
- REVEL 0.07
- CADD 23.30
- PolyPhen-2 0.17
- SIFT 0.07
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available