S25N (p.Ser25Asn) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
S25N (p.Ser25Asn) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
S25N (p.Ser25Asn) variant details
- p.Ser25Asn
- gnomAD rs1665184257
- Missense
- Variant Prioritization Score for Impact Estimate 0.214
- REVEL 0.03
- CADD 23.30
- PolyPhen-2 0.01
- SIFT 0.05
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available