R65W (p.Arg65Trp) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
R65W (p.Arg65Trp) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
R65W (p.Arg65Trp) variant details
- p.Arg65Trp
- cosmic curated COSV10468
- 1000Genomes rs377491451
- ESP rs377491451
- ExAC rs377491451
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.08
- CADD 22.90
- PolyPhen-2 0.00
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available