R10P (p.Arg10Pro) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
R10P (p.Arg10Pro) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
R10P (p.Arg10Pro) variant details
- p.Arg10Pro
- ExAC rs746792662
- TOPMed rs746792662
- gnomAD rs746792662
- Missense
- Variant Prioritization Score for Impact Estimate 0.406
- REVEL 0.21
- CADD 28.80
- PolyPhen-2 0.69
- SIFT 0.04
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available