R10G (p.Arg10Gly) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
R10G (p.Arg10Gly) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
R10G (p.Arg10Gly) variant details
- p.Arg10Gly
- NCI-TCGA Cosmic COSV1008
- cosmic curated COSV10082
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.12
- CADD 24.50
- PolyPhen-2 0.34
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available