K86R (p.Lys86Arg) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
K86R (p.Lys86Arg) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
K86R (p.Lys86Arg) variant details
- p.Lys86Arg
- ESP rs373081722
- ExAC rs373081722
- TOPMed rs373081722
- gnomAD rs373081722
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.21
- CADD 23.30
- PolyPhen-2 0.21
- SIFT 0.18
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available