K59R (p.Lys59Arg) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
K59R (p.Lys59Arg) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
K59R (p.Lys59Arg) variant details
- p.Lys59Arg
- gnomAD rs1665053768
- Missense
- Variant Prioritization Score for Impact Estimate 0.334
- REVEL 0.14
- CADD 23.20
- PolyPhen-2 0.28
- SIFT 0.09
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available