K23T (p.Lys23Thr) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
K23T (p.Lys23Thr) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
K23T (p.Lys23Thr) variant details
- p.Lys23Thr
- gnomAD rs1416842124
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- REVEL 0.22
- CADD 24.70
- PolyPhen-2 0.61
- SIFT 0.68
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available