K15R (p.Lys15Arg) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
K15R (p.Lys15Arg) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
K15R (p.Lys15Arg) variant details
- p.Lys15Arg
- gnomAD rs1334838918
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.30
- CADD 29.40
- PolyPhen-2 0.58
- SIFT 0.00
- Most common in the HGDP:YAKUT population (allele frequency 0.04)
- Structural context available