I64S (p.Ile64Ser) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
I64S (p.Ile64Ser) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
I64S (p.Ile64Ser) variant details
- p.Ile64Ser
- ExAC rs766952486
- gnomAD rs766952486
- Missense
- Variant Prioritization Score for Impact Estimate 0.305
- REVEL 0.10
- CADD 21.90
- PolyPhen-2 0.01
- SIFT 0.73
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available