I37F (p.Ile37Phe) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
I37F (p.Ile37Phe) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
I37F (p.Ile37Phe) variant details
- p.Ile37Phe
- TOPMed rs1285064497
- gnomAD rs1285064497
- Missense
- Variant Prioritization Score for Impact Estimate 0.186
- REVEL 0.06
- CADD 24.40
- PolyPhen-2 0.01
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available