G98S (p.Gly98Ser) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
G98S (p.Gly98Ser) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
G98S (p.Gly98Ser) variant details
- p.Gly98Ser
- TOPMed rs1558241049
- gnomAD rs1558241049
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.11
- CADD 18.70
- PolyPhen-2 0.01
- SIFT 0.49
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available