G61S (p.Gly61Ser) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
G61S (p.Gly61Ser) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
G61S (p.Gly61Ser) variant details
- p.Gly61Ser
- Ensembl rs2102747224
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.13
- CADD 23.00
- PolyPhen-2 0.10
- SIFT 0.11
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available