G61D (p.Gly61Asp) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
G61D (p.Gly61Asp) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
G61D (p.Gly61Asp) variant details
- p.Gly61Asp
- ExAC rs758791748
- TOPMed rs758791748
- gnomAD rs758791748
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- REVEL 0.15
- CADD 22.60
- PolyPhen-2 0.21
- SIFT 0.09
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available