G17R (p.Gly17Arg) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
G17R (p.Gly17Arg) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
G17R (p.Gly17Arg) variant details
- p.Gly17Arg
- ExAC rs771934563
- gnomAD rs771934563
- Missense
- Variant Prioritization Score for Impact Estimate 0.611
- REVEL 0.56
- CADD 29.50
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available