C21Y (p.Cys21Tyr) variant of PARP1 (Poly [ADP-ribose] polymerase 1)
C21Y (p.Cys21Tyr) in PARP1 (Poly [ADP-ribose] polymerase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data and structural context.
C21Y (p.Cys21Tyr) variant details
- p.Cys21Tyr
- gnomAD rs1665184470
- Missense
- Variant Prioritization Score for Impact Estimate 0.815
- REVEL 0.92
- CADD 29.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available