R26W (p.Arg26Trp) variant of PALB2 (Partner and localizer of BRCA2)
R26W (p.Arg26Trp) in PALB2 (Partner and localizer of BRCA2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R26W (p.Arg26Trp) variant details
- p.Arg26Trp
- Ensembl rs2142460618
- Missense
- Variant Prioritization Score for Impact Estimate 0.297
- REVEL 0.10
- CADD 28.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 0.00044)
- Structural context available