K60T (p.Lys60Thr) variant of PADI4 (Q9UM07)
K60T (p.Lys60Thr) in PADI4 (Q9UM07) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
K60T (p.Lys60Thr) variant details
- p.Lys60Thr
- NCI-TCGA Cosmic COSV6492
- cosmic curated COSV64922
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.198
- REVEL 0.10
- CADD 22.80
- PolyPhen-2 0.91
- SIFT 0.41
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available