S15Y (p.Ser15Tyr) variant of ORC1 (Q13415)
S15Y (p.Ser15Tyr) in ORC1 (Q13415) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
S15Y (p.Ser15Tyr) variant details
- p.Ser15Tyr
- gnomAD 13-40793234-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- REVEL 0.23
- CADD 15.60
- PolyPhen-2 0.23
- SIFT 1.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available