P26L (p.Pro26Leu) variant of NUDT15 (Q9NV35)
P26L (p.Pro26Leu) in NUDT15 (Q9NV35) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
P26L (p.Pro26Leu) variant details
- p.Pro26Leu
- ExAC rs775476759
- gnomAD rs775476759
- Missense
- Variant Prioritization Score for Impact Estimate 0.444
- REVEL 0.27
- MetaLR 0.13
- MetaSVM -1.03
- CADD 25.30
- PolyPhen-2 0.99
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available