C23G (p.Cys23Gly) variant of NUDT15 (Q9NV35)
C23G (p.Cys23Gly) in NUDT15 (Q9NV35) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
C23G (p.Cys23Gly) variant details
- p.Cys23Gly
- NCI-TCGA Cosmic COSV9932
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0939
- REVEL 0.08
- MetaLR 0.00
- MetaSVM -0.97
- CADD 0.17
- PolyPhen-2 0.00
- SIFT 0.49
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.6e-05)
- Structural context available