S4C (p.Ser4Cys) variant of NTRK3 (NT-3 growth factor receptor)
S4C (p.Ser4Cys) in NTRK3 (NT-3 growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
S4C (p.Ser4Cys) variant details
- p.Ser4Cys
- cosmic curated COSV58146
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.10
- CADD 22.90
- PolyPhen-2 0.63
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 5.6e-06)
- Structural context available