R14W (p.Arg14Trp) variant of NTRK3 (NT-3 growth factor receptor)
R14W (p.Arg14Trp) in NTRK3 (NT-3 growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
R14W (p.Arg14Trp) variant details
- p.Arg14Trp
- cosmic curated COSV10609
- ExAC rs111731219
- TOPMed rs111731219
- gnomAD rs111731219
- Missense
- Variant Prioritization Score for Impact Estimate 0.492
- REVEL 0.45
- CADD 25.00
- PolyPhen-2 0.99
- SIFT 0.05
- Most common in the Middle Eastern population (allele frequency 0.00037)
- Structural context available