S62R (p.Ser62Arg) variant of NTRK2 (Q16620)
S62R (p.Ser62Arg) in NTRK2 (Q16620) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes structural context.
S62R (p.Ser62Arg) variant details
- p.Ser62Arg
- rs915858967
- ClinGen CA374004913
- cosmic curated COSV52887
- ClinVar RCV002048211
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.451
- AlphaMissense 0.22
- MetaLR 0.34
- MetaSVM -0.45
- PolyPhen-2 0.89
- SIFT 0.24
- MutPred 0.28
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available