P33A (p.Pro33Ala) variant of NTRK2 (Q16620)
P33A (p.Pro33Ala) in NTRK2 (Q16620) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
P33A (p.Pro33Ala) variant details
- p.Pro33Ala
- NCI-TCGA Cosmic COSV5288
- cosmic curated COSV52886
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.809
- REVEL 0.83
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available