P10S (p.Pro10Ser) variant of NTRK2 (Q16620)
P10S (p.Pro10Ser) in NTRK2 (Q16620) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
P10S (p.Pro10Ser) variant details
- p.Pro10Ser
- TOPMed rs1359560976
- gnomAD rs1359560976
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.448
- REVEL 0.34
- CADD 23.20
- PolyPhen-2 0.60
- SIFT 0.25
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available