C45Y (p.Cys45Tyr) variant of NTRK2 (Q16620)
C45Y (p.Cys45Tyr) in NTRK2 (Q16620) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.87 / 1. The record also includes population frequency data and structural context.
C45Y (p.Cys45Tyr) variant details
- p.Cys45Tyr
- NCI-TCGA Cosmic COSV5285
- NCI-TCGA Cosmic COSV5286
- cosmic curated COSV52864
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.874
- REVEL 0.92
- CADD 29.60
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available