Y41C (p.Tyr41Cys) variant of NRXN2 (Neurexin-2)
Y41C (p.Tyr41Cys) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
Y41C (p.Tyr41Cys) variant details
- p.Tyr41Cys
- gnomAD rs1249976861
- Missense
- Variant Prioritization Score for Impact Estimate 0.567
- REVEL 0.63
- MetaLR 0.54
- MetaSVM -0.08
- CADD 28.30
- PolyPhen-2 0.72
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 5.3e-05)
- Structural context available