W7R (p.Trp7Arg) variant of NRXN2 (Neurexin-2)
W7R (p.Trp7Arg) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
W7R (p.Trp7Arg) variant details
- p.Trp7Arg
- TOPMed rs977042363
- gnomAD rs977042363
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.07
- MetaLR 0.11
- MetaSVM -0.96
- CADD 22.60
- PolyPhen-2 0.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available