V137L (p.Val137Leu) variant of NRXN2 (Neurexin-2)
V137L (p.Val137Leu) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
V137L (p.Val137Leu) variant details
- p.Val137Leu
- TOPMed rs1337883189
- gnomAD rs1337883189
- Missense
- Variant Prioritization Score for Impact Estimate 0.473
- REVEL 0.35
- MetaLR 0.46
- MetaSVM -0.22
- CADD 21.70
- PolyPhen-2 0.08
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available