T59N (p.Thr59Asn) variant of NRXN2 (Neurexin-2)
T59N (p.Thr59Asn) in NRXN2 (Neurexin-2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
T59N (p.Thr59Asn) variant details
- p.Thr59Asn
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.809
- REVEL 0.84
- MetaLR 0.83
- MetaSVM 0.84
- CADD 25.80
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available