T105K (p.Thr105Lys) variant of NRXN2 (Neurexin-2)
T105K (p.Thr105Lys) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
T105K (p.Thr105Lys) variant details
- p.Thr105Lys
- TOPMed rs1337021462
- gnomAD rs1337021462
- Missense
- Variant Prioritization Score for Impact Estimate 0.462
- REVEL 0.37
- MetaLR 0.26
- MetaSVM -0.77
- CADD 19.60
- PolyPhen-2 0.03
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 3.6e-05)
- Structural context available