R88W (p.Arg88Trp) variant of NRXN2 (Neurexin-2)
R88W (p.Arg88Trp) in NRXN2 (Neurexin-2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
R88W (p.Arg88Trp) variant details
- p.Arg88Trp
- ExAC rs781507844
- gnomAD rs781507844
- Missense
- Variant Prioritization Score for Impact Estimate 0.594
- REVEL 0.66
- MetaLR 0.53
- MetaSVM -0.01
- CADD 32.00
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available